The competition which will feature teams from 32 countries, will be taking place from November 21 to December 18.
If the Super Eagles team defeats the Blacks Stars of Ghana, this would be their seventh World Cup appearance.
The first leg is billed for the Baba Yara Stadium on Friday (today) March 25, while the second leg holds in Abuja on Tuesday March 29.
FIFA recently increased the qualifying bonus from €10m to €12.2m to help teams that qualify for the tournament to prepare well.
The Nigeria Football Federation received €10m from FIFA when they qualified for the 2018 World Cup in Russia.
Meanwhile, the build-up to the fixture has been spiced up by talk of the long rivalry between the two nations, dating all the way back to their first meeting in 1951, when the Nigerians romped to a 5-0 victory over their neighbours.
Nigeria have kept a clean sheet in each of their last three meetings in World Cup qualifiers against Ghana – winning one and drawing two, although they have failed to score in three of the previous four such meetings themselves.
Ghana remain unbeaten in their last five games against Nigeria in all competitions – winning three and drawing two.
There is just a single goal scored across the last three meetings (Asamoah Gyan’s winner for Ghana at the 2010 AFCON), with the last two encounters ending goalless (a friendly in 2010 and most recently at the African Nations Championship in 2014).
Ghana and Nigeria shared exactly the same records in the second round of qualifying for the 2022 World Cup, both winning four, drew one and losing one of their six matches.
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